Preleukemia and leukemia in polycythemia vera

Preleukemia and leukemia in polycythemia vera.

A group of 76 polycythemia vera patients was followed prospectively with bone marrow examinations at regular intervals. Six terminated in acute leukemia, preceded by an indolent preleukemic phase succeeded by a very fulminant leukemia. At autopsy, all patients had extramedullary hematopoiesis. In one of them, only the bone marrow was leukemic, suggesting that it was the primary site of this tra...

Muramidase in polycythemia vera.

Immunotherapy and polycythemia vera

Polycythemia vera (PV) is a chronic myeloproliferative disorder characterized by abnormal growth of erythroid precursors in the bone marrow. Almost all patients with PV, around 97%, have a mutation in Janus kinase 2 (JAK2). It is through the activation of JAK/Signal Transducers and Activators of Transcription (STAT) protein signaling pathway that the JAK2 mutation is thought to induce cellular ...

Myeloproliferative Syndrome with Leukemia Preceding Polycythemia Vera : A Case Report

SSOCIATED PROLIFERATION of the various hematologic elements in the marrow, although recognized for some time,2 has recently been the subject of renewed interest.3’8 A close relationship between myelofibrosis and he leukoerythroblastic conditions was demonstrated by Vaughan and HarrisonT in 1939. They suggested that an unknown stimulus acting on the primitive mesenchymal reticulum cell may be re...

Myeloproliferative Syndrome with Leukemia Preceding Polycythemia Vera : A Case Report

SSOCIATED PROLIFERATION of the various hematologic elements in the marrow, although recognized for some time,2 has recently been the subject of renewed interest.3’8 A close relationship between myelofibrosis and he leukoerythroblastic conditions was demonstrated by Vaughan and HarrisonT in 1939. They suggested that an unknown stimulus acting on the primitive mesenchymal reticulum cell may be re...